Kelis was one of several artists

Kelis was one of several artists whose careers Hugo and Williams have helped launch; artists such as the Clipse, Vanessa Marquez and Justin Timberlake's solo career were also closely tied to the Neptunes' involvement. They have also helped re-launch the careers of Snoop Dogg, Robin Thicke and Mystikal.

In 2001, The Neptunes gained their first worldwide hit with Britney Spears' single, "I'm A Slave 4 U", which reached #1 in several countries in Europe and South America. The following year they reached #1 in the U.S. with Nelly's single, "Hot in Herre". In August of the same year, The Neptunes were named "Producers of the Year" at both The Source Awards and the Billboard Music Awards.

In 2003, they released a self-credited album called The Neptunes Present... Clones, featuring songs and remixes from various Star Trak artists. This album topped the US Billboard 200 Albums Chart.

The Neptunes went home with two Grammy Awards in 2004, one for "Producer of the Year, Non-Classical", and another for "Best Pop Vocal Album" for their work on Justin Timberlake's No.2 Billboard hit Justified. They also gained their first UK #1, again with Nelly, and Flap Your Wings.

A survey in August 2003 found the Neptunes produced almost 20% of songs played on British radio. A similar survey in the US had them at 43%.[2] This level of radio domination is unprecedented in recent years, and highlights the effect they have had on music and production development in this era.

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